PNANO4BONE eng

Nanovectors engineered for plasma enhanced theranostics in regenerative medicine 

Main information
Project type: M-ERA.NET (ERA-NET for materials research and innovation) in the Horizon 2020 framework
Reference number: ID347640 Unisono
Agreement number: UMO-2016/22/Z/ST8

Start Date: 2017-08-01
End Date: 2020-07-31
Duration: 36 months

Budget:
• 1 445 868 Euro for Consortium
• 577930 PLN for LUT
Reimbursement rate: 100% of the action's eligible costs

List of participants:

  1. Luxembourg Institute of Science and Technology- coordinator
  2. Medical University of Lublin- Chair of Biochemistry and Biotechnology, Farmaceutical Faculty (Poland)
  3. Laboratory of Plasma Technology and Renewable Energy, Institute of Electrotechnics and Electrotechnology, Lublin University of Technology (Poland)
  4. Universite Catholique de Louvain (Belgium)
  5. Polytechnic University of Catalonia (Spain)
  6. Cellon SA (Luxembourg)

Project description
In the PNANO4BONE project, novel nanovectors engineered for plasma enhanced theranostics in bone tissue regeneration will be dispersed in polymer-based implantable scaffolds to favor the adhesion, proliferation and differentiation of living cells into the scaffold. The nanovectors will be designed to deliver molecules needed to improve the cell behavior in/on the scaffold both through a controlled release of drug/biomolecules stored inside the nanovectors but also through a local production of short lifetime reactive species, which will allow to program the fate of the living cells through controlled oxidative or nitrosative stresses. These reactive species will be generated through the exposition of the scaffold/nanovectors to cold atmospheric plasma (ionized gas) optimized for tissue treatments. In order to generate short lifetime reactive species from long lifetime ones generated by plasma, the novel nanovectors will have catalytic abilities operating in physiological conditions. The multifunctional nanovectors will also allow a better following of regenerative processes with fluorescent probes aiming to detect dead or differentiated stem cells and will improve the mechanical properties of the scaffold.

Person responsible for the LUT's research part:

Prof. Joanna Pawłat

Laboratory of Plasma Technology and Renewable Energy
Institute of Electrotechnics and Electrotechnology
Electrical Engineering and Computer Science Faculty
Lublin University of Technology
ul. Nadbystrzycka 38A
20-618 Lublin
tel/fax. +48-81-5384289
j.pawlat@pollub.pl